Research workbench
Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor
Analyse Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4LF3
- Type
- protein
- Length
- 1,079 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fab heavy chain; Fab light chain; Glucagon receptor
- UniProt
- P47871
- Pockets
- 11 · best druggability 0.57
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Fab heavy chain | protein | 214 | 6% helix, 50% strand | — |
| B, E | Fab light chain | protein | 231 | 9% helix, 53% strand | — |
| C | Glucagon receptor | protein | 95 | 21% helix, 25% strand | P47871 |
| F | Glucagon receptor | protein | 94 | 27% helix, 26% strand | P47871 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 221 | 0.57 | 0.80 | 30 | empty |
| 2 | 200 | 0.54 | 0.78 | 29 | empty |
| 3 | 178 | 0.53 | 0.79 | 36 | empty |
| 4 | 243 | 0.49 | 0.74 | 37 | empty |
| 5 | 158 | 0.46 | 0.76 | 22 | empty |
Interfaces
7 interfaces between chains.
- D–E · 1781 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 1725 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 639 Ų buried · 10 hydrogen bonds · protein-protein
- E–F · 614 Ų buried · 11 hydrogen bonds · protein-protein
- B–E · 348 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide (disulfide).
Compared structures
- 4LF3 · Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor · the same entry in another collection · chain A against A, TM-score 1.00
- P47871 · AlphaFold monomer V2.0 prediction for glucagon receptor (P47871) · a predicted model of the same protein · chain F against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47871
- Elsewhere: RCSB PDB 4LF3 · PDBe 4LF3 · UniProt P47871
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