UniProt P47871
Glucagon receptor (P47871)
Glucagon receptor (UniProt P47871), EC 3.2.1.17: 25 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 40 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P47871
- Protein
- Glucagon receptor
- EC
- 3.2.1.17
- Experimental structures
- 25
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 40 · 5 records with a druggable one
Structures
26 records of P47871 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3CZF | Crystal structure of HLA-B*2709 complexed with the glucagon receptor (GR) peptide (residues 412-420) | x-ray diffraction | C | — | — |
| 3CZF | Crystal structure of HLA-B*2709 complexed with the glucagon receptor (gr) peptide (residues 412-420) | x-ray diffraction | C | — | — |
| 4ERS | A Molecular Basis for Negative Regulation of the Glucagon Receptor | x-ray diffraction | A | — | — |
| 4ERS | A molecular basis for negative regulation of the glucagon receptor | x-ray diffraction | A | — | — |
| 4L6R | Structure of the class B human glucagon G protein coupled receptor | x-ray diffraction | A | — | — |
| 4L6R | Structure of the class B human glucagon G protein coupled receptor | x-ray diffraction | A | — | — |
| 4LF3 | Inhibitory Mechanism of an Allosteric Antibody Targeting the Glucagon Receptor | x-ray diffraction | C, F | — | — |
| 4LF3 | Inhibitory mechanism of an allosteric antibody targeting the glucagon receptor | x-ray diffraction | C, F | — | — |
| 5EE7 | Crystal structure of the human glucagon receptor (GCGR) in complex with the antagonist MK-0893 | x-ray diffraction | A | 5MV, OLA | — |
| 5EE7 | Crystal structure of the human glucagon receptor (gcgr) in complex with the antagonist mk-0893 | x-ray diffraction | A | — | — |
| 5XEZ | Structure of the Full-length glucagon class B G protein-coupled receptor | x-ray diffraction | A, B | NAG, 97V | 12 (best 0.78) |
| 5XEZ | Structure of the full-length glucagon class B G protein-coupled receptor | x-ray diffraction | A, B | NAG, 97V | — |
| 5XF1 | Structure of the Full-length glucagon class B G protein-coupled receptor | x-ray diffraction | A, B | NAG, 97V | — |
| 5XF1 | Structure of the full-length glucagon class B G protein-coupled receptor | x-ray diffraction | A, B | NAG, 97V | — |
| 5YQZ | Structure of the glucagon receptor in complex with a glucagon analogue | x-ray diffraction | R | NAG, PO4 | — |
| 6LMK | Cryo-EM structure of the human glucagon receptor in complex with gs | electron microscopy | R | — | — |
| 6LML | Cryo-EM structure of the human glucagon receptor in complex with GI1 | electron microscopy | R | — | — |
| 6WHC | Cryoem structure of the glucagon receptor with a dual-agonist peptide | electron microscopy | R | — | — |
| 6WPW | GCGR-Gs signaling complex bound to a designed glucagon derivative | electron microscopy | R | — | — |
| 6WPW | Gcgr-gs signaling complex bound to a designed glucagon derivative | electron microscopy | R | — | — |
| 7V35 | Cryo-EM structure of the GIPR/GLP-1R/GCGR triagonist peptide 20-bound human gcgr-gs complex | electron microscopy | R | D6M | — |
| 8JIQ | Cryo-EM structure of the GLP-1R/GCGR dual agonist Peptide 15-bound human GCGR-Gs complex | electron microscopy | R | — | 6 (best 0.77) |
| 8JRU | Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | electron microscopy | R | PIO | 5 (best 0.75) |
| 8WG8 | Cryo-EM structures of peptide free and Gs-coupled GCGR | electron microscopy | R | — | 6 (best 0.73) |
| 8YW5 | Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex | electron microscopy | R | — | 11 (best 0.74) |
| P47871 | AlphaFold monomer V2.0 prediction for glucagon receptor (P47871) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 5 records
- 97V · 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl) phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl) benzamide · in 4 records
- 5MV · 3-[[4-[(1~{S})-1-[3-[3,5-bis(chloranyl)phenyl]-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]phenyl]carbonylamino]propanoic acid · in 1 record
- D6M · N-hexadecanoyl-L-glutamic acid · in 1 record
- OLA · Oleic acid · in 1 record
- PIO · [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2, 3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate · in 1 record
- PO4 · Phosphate ion · in 1 record
Experiment against prediction
- 4LF3 chain F against the predicted model P47871: TM-score 0.98, RMSD 0.55 Å
- 4LF3 chain F against the predicted model P47871: TM-score 0.98, RMSD 0.55 Å
- 4LF3 chain C against the predicted model P47871: TM-score 0.97, RMSD 0.59 Å
- 4LF3 chain C against the predicted model P47871: TM-score 0.97, RMSD 0.59 Å
- 6WPW chain R against the predicted model P47871: TM-score 0.97, RMSD 1.35 Å
- 6WPW chain R against the predicted model P47871: TM-score 0.97, RMSD 1.35 Å
- 6LMK chain R against the predicted model P47871: TM-score 0.97, RMSD 1.36 Å
- 4ERS chain A against the predicted model P47871: TM-score 0.96, RMSD 1.31 Å
- 4ERS chain A against the predicted model P47871: TM-score 0.96, RMSD 1.31 Å
- 6LML chain R against the predicted model P47871: TM-score 0.95, RMSD 1.90 Å
Elsewhere
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