Carbonic anhydrase II complexed with al-8520 2H-THIENO[3,2-E]-1,2- thiazine-6-sulfonamide, 4-amino-3,4-dihydro-2-(3-methoxypropyl)-, 1, 1-dioxide, (R)

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 31% strand (DSSP).

Ligands and binding sites

• INM · 4-amino-6-[N-(3-methoxylpropyl)-2H-thieno[3,2-e][1,2]thiazine 1,1-dioxide]-sulfonamide · ligand · chains A
• ZN · Zinc ion · metal · chains A
• HG · Mercury (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 1I90 · Carbonic anhydrase II complexed with al-8520 2H-THIENO[3,2-E]-1,2-thiazine-6-sulfonamide… · the same entry in another collection · chain A against A, TM-score 1.00
• P00918 · AlphaFold monomer V2.0 prediction for carbonic anhydrase 2 (P00918) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P00918
• Elsewhere: RCSB PDB 1I90 · PDBe 1I90 · UniProt P00918