Research workbench
Crystal structures of human P70S6K1-T389E
Analyse Crystal structures of human P70S6K1-T389E in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4L45
- Type
- protein
- Length
- 317 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RPS6KB1 protein
- UniProt
- Q7Z721
- Ligands
- 5FI
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RPS6KB1 protein | protein | 317 | 33% helix, 15% strand | Q7Z721 |
Ligands and binding sites
- 5FI · 2-{[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl}-5-(trifluoromethyl)-1H-benzimidazole · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 336 | 0.76 | 0.86 | 34 | 5FI |
| 2 | 262 | 0.54 | 0.76 | 27 | empty |
| 3 | 100 | 0.49 | 0.80 | 18 | empty |
| 4 | 127 | 0.42 | 0.75 | 21 | empty |
| 5 | 83 | 0.32 | 0.73 | 17 | empty |
Compared structures
- 4L45 · Crystal structures of human p70S6K1-T389E · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7Z721
- Elsewhere: RCSB PDB 4L45 · PDBe 4L45 · UniProt Q7Z721
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