Research workbench
Structural and functional analysis of a putative substrate access tunnel in the cytosolic domain of human anion exchanger 1
Analyse Structural and functional analysis of a putative substrate access tunnel in the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KY9
- Type
- protein
- Length
- 551 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Band 3 anion transport protein
- UniProt
- P02730
- Pockets
- 4 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Band 3 anion transport protein | protein | 276 | 37% helix, 26% strand | P02730 |
| P | Band 3 anion transport protein | protein | 275 | 35% helix, 27% strand | P02730 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 503 | 0.77 | 0.84 | 60 | empty |
| 2 | 583 | 0.74 | 0.82 | 52 | empty |
| 3 | 123 | 0.69 | 0.90 | 22 | empty |
| 4 | 75 | 0.56 | 0.87 | 19 | empty |
Interfaces
1 interface between chains.
- A–P · 2697 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 4KY9 · Structural and Functional Analysis of a Putative Substrate Access Tunnel in the Cytosolic… · the same entry in another collection · chain A against A, TM-score 1.00
- P02730 · AlphaFold monomer V2.0 prediction for band 3 anion transport protein (P02730) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02730
- Elsewhere: RCSB PDB 4KY9 · PDBe 4KY9 · UniProt P02730
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