Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2) with (S)-{2-[2-(5-cyano-3-hydroxy-pyridin-2-yl)-thiazol-4-yl]- acetylamino}-phenyl-acetic acid

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 27% strand (DSSP).

Ligands and binding sites

• 1QA · (2S)-({[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetyl}amino)(phenyl)ethanoic acid · ligand · chains A
• FE2 · Fe (II) ion · metal · chains A
• SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4KBZ · Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9GZT9
• Elsewhere: RCSB PDB 4KBZ · PDBe 4KBZ · UniProt Q9GZT9