Research workbench
Structure of MAP kinase in complex with a docking peptide
Analyse Structure of MAP kinase in complex with a docking peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4KA3
- Type
- protein
- Length
- 348 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14; TGF-beta-activated kinase 1 and MAP3K7-binding…
- EC
- 2.7.11.24
- UniProt
- P47811, Q15750
- Pockets
- 3 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 340 | 41% helix, 16% strand | P47811 |
| B | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 | protein | 8 | 0% helix, 0% strand | Q15750 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.63 | 0.79 | 32 | empty |
| 2 | 164 | 0.47 | 0.76 | 22 | empty |
| 3 | 146 | 0.45 | 0.76 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 458 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4KA3 · Structure of MAP kinase in complex with a docking peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P47811 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 14 (P47811) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q15750 · AlphaFold monomer V2.0 prediction for TGF-beta-activated kinase 1 and MAP3K7-binding… · a predicted model of the same protein · chain B against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47811
- Every structure of UniProt Q15750
- Elsewhere: RCSB PDB 4KA3 · PDBe 4KA3 · UniProt P47811 · UniProt Q15750
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.