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Crystal structure of full-length mouse alphae-catenin

Analyse Crystal structure of full-length mouse alphae-catenin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4K1N
Type: protein
Length: 1,040 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Catenin alpha-1
UniProt: P26231
Pockets: 11 · best druggability 0.79

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Catenin alpha-1	protein	520	78% helix, 0% strand	P26231

Pockets

11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	725	0.79	0.83	102	empty
2	589	0.73	0.81	72	empty
3	215	0.65	0.84	42	empty
4	99	0.62	0.88	21	empty
5	510	0.61	0.75	46	empty

Interfaces

1 interface between chains.

A–B · 1477 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4K1N · Crystal structure of full-length mouse alphaE-catenin · the same entry in another collection · chain A against A, TM-score 1.00
P26231 · AlphaFold monomer V2.0 prediction for catenin alpha-1 (P26231) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P26231
Elsewhere: RCSB PDB 4K1N · PDBe 4K1N · UniProt P26231

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