UniProt P26231
Catenin alpha-1 (P26231)
Catenin alpha-1 (UniProt P26231): 17 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P26231
- Protein
- Catenin alpha-1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 17 · 3 records with a druggable one
Structures
18 records of P26231 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DOV | Crystal structure of the alpha-catenin dimerization domain | x-ray diffraction | A | — | — |
| 1DOV | Crystal structure of the alpha-catenin dimerization domain | x-ray diffraction | A | — | — |
| 1DOW | Crystal structure of a chimera of beta-catenin and alpha-catenin | x-ray diffraction | A | — | — |
| 1DOW | Crystal structure of a chimera of beta-catenin and alpha- catenin | x-ray diffraction | A | — | — |
| 4E17 | Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin | x-ray diffraction | B | — | — |
| 4E17 | Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin | x-ray diffraction | B | — | — |
| 4E18 | Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin | x-ray diffraction | B | — | — |
| 4E18 | Alpha-E-catenin is an autoinhibited molecule that co-activates vinculin | x-ray diffraction | B | — | — |
| 4K1N | Crystal structure of full-length mouse alphaE-catenin | x-ray diffraction | A, B | — | — |
| 4K1N | Crystal structure of full-length mouse alphae-catenin | x-ray diffraction | A, B | — | — |
| 5Y04 | Crystal Structure of the complex between the vinculin D1 domain and alphaE-catenin | x-ray diffraction | B | — | 1 (best 0.58) |
| 5Y04 | Crystal structure of the complex between the vinculin D1 domain and alphae-catenin | x-ray diffraction | B | — | — |
| 6DV1 | Crystal structure of the alpha-E-catenin actin-binding domain | x-ray diffraction | A, B | BR, SO4 | — |
| 6O3E | mouse aE-catenin 82-883 | x-ray diffraction | A, B | — | 9 (best 0.73) |
| 6O3E | Mouse ae-catenin 82-883 | x-ray diffraction | A, B | — | — |
| 6WVT | Structural basis of alphae-catenin - F-actin catch bond behavior | electron microscopy | K, L, N, O, Q, X | — | — |
| 9DVA | F-actin binding interface of alpha-E-catenin ABD (cadherin-catenin complex) and afadin | electron microscopy | F, H | — | 7 (best 0.81) |
| P26231 | AlphaFold monomer V2.0 prediction for catenin alpha-1 (P26231) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1DOW chain A against the predicted model P26231: TM-score 0.97, RMSD 0.90 Å
- 1DOW chain A against the predicted model P26231: TM-score 0.97, RMSD 0.90 Å
- 6DV1 chain A against the predicted model P26231: TM-score 0.95, RMSD 1.46 Å
- 6DV1 chain B against the predicted model P26231: TM-score 0.94, RMSD 1.67 Å
- 1DOV chain A against the predicted model P26231: TM-score 0.92, RMSD 1.74 Å
- 1DOV chain A against the predicted model P26231: TM-score 0.92, RMSD 1.74 Å
- 4E17 chain B against the predicted model P26231: TM-score 0.88, RMSD 0.54 Å
- 4E17 chain B against the predicted model P26231: TM-score 0.88, RMSD 0.54 Å
- 6O3E chain B against the predicted model P26231: TM-score 0.88, RMSD 3.19 Å
- 6O3E chain B against the predicted model P26231: TM-score 0.88, RMSD 3.19 Å
Elsewhere
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