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Structural basis for host specificity of factor H binding by streptococcus pneumoniae
Analyse Structural basis for host specificity of factor H binding by streptococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4K12
- Type
- protein
- Length
- 146 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Complement factor H; Choline binding protein a
- UniProt
- P08603, G6W2B2
- Pockets
- 1 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Complement factor H | protein | 64 | 5% helix, 45% strand | P08603 |
| B | Choline binding protein a | protein | 82 | 83% helix, 0% strand | G6W2B2 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 168 | 0.56 | 0.81 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 686 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 4K12 · Structural Basis for Host Specificity of Factor H Binding by Streptococcus pneumoniae · the same entry in another collection · chain A against A, TM-score 1.00
- P08603 · AlphaFold monomer V2.0 prediction for complement factor H (P08603) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08603
- Every structure of UniProt G6W2B2
- Elsewhere: RCSB PDB 4K12 · PDBe 4K12 · UniProt P08603 · UniProt G6W2B2
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