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The structure of 1NA in complex with src T338G

Analyse The structure of 1NA in complex with src T338G in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4K11
Type: protein
Length: 448 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Proto-oncogene tyrosine-protein kinase src
EC: 2.7.10.2
UniProt: P12931
Ligands: 0J9
Pockets: 5 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 23% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Proto-oncogene tyrosine-protein kinase src (EC 2.7.10.2)	protein	448	28% helix, 23% strand	P12931

Ligands and binding sites

0J9 · 1-tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	499	0.77	0.84	57	0J9
2	841	0.69	0.75	63	empty
3	437	0.59	0.75	40	empty
4	59	0.34	0.77	15	empty
5	64	0.33	0.76	17	empty

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

4K11 · The structure of 1NA in complex with Src T338G · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12931
Elsewhere: RCSB PDB 4K11 · PDBe 4K11 · UniProt P12931

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