UniProt P12931
Isoform 2 of Proto-oncogene tyrosine-protein kinase Src (P12931)
Isoform 2 of Proto-oncogene tyrosine-protein kinase Src (UniProt P12931), EC 2.7.10.2: 130 experimental structures on GenesisL1, 6 ligands bound, 7 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P12931
- Protein
- Isoform 2 of Proto-oncogene tyrosine-protein kinase Src
- EC
- 2.7.10.2
- Experimental structures
- 130
- Predicted models
- 0
- Ligands
- 6
- Pockets
- 7 · 2 records with a druggable one
Structures
130 records of P12931 in the MolNFT archive: 130 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A07 | C-src (SH2 domain) complexed with ACE-malonyl tyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A07 | C-src (SH2 domain) complexed with ACE-malonyl tyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A08 | C-src (SH2 domain) complexed with ACE-difluoro phosphotyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A08 | C-src (SH2 domain) complexed with ACE-difluoro phosphotyr-glu-(N,N- dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A09 | C-src (SH2 domain) complexed with ace-formyl phosphotyr-glu-(n,n-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A09 | C-src (SH2 domain) complexed with ACE-formyl phosphotyr-glu-(N,N- dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A1A | C-src (SH2 domain with C188A mutation) complexed with ACE-formyl phosphotyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A1A | C-src (SH2 domain with C188A mutation) complexed with ACE-formyl phosphotyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A1B | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A1B | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(N,N-dipentyl amine) | x-ray diffraction | A, B | — | — |
| 1A1C | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(N-me(-(CH2)3-cyclopentyl)) | x-ray diffraction | A, B | — | — |
| 1A1C | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(N-me(-(CH2)3- cyclopentyl)) | x-ray diffraction | A, B | — | — |
| 1A1E | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(3-butylpiperidine) | x-ray diffraction | A, B | — | — |
| 1A1E | C-src (SH2 domain) complexed with ACE-phosphotyr-glu-(3- butylpiperidine) | x-ray diffraction | A, B | — | — |
| 1FMK | Crystal structure of human tyrosine-protein kinase C-src | x-ray diffraction | A | — | — |
| 1FMK | Crystal structure of human tyrosine-protein kinase C-src | x-ray diffraction | A | — | — |
| 1HCS | NMR structure of the human src SH2 domain complex | solution nmr | B | — | — |
| 1HCS | NMR structure of the human src SH2 domain complex | solution nmr | B | — | — |
| 1HCT | NMR structure of the human src SH2 domain complex | solution nmr | B | — | — |
| 1HCT | NMR structure of the human src SH2 domain complex | solution nmr | B | — | — |
| 1KSW | Structure of Human c-Src Tyrosine Kinase (Thr338Gly Mutant) in Complex with N6-benzyl ADP | x-ray diffraction | A | — | — |
| 1KSW | Structure of human C-src tyrosine kinase (THR338GLY mutant) in complex with N6-benzyl ADP | x-ray diffraction | A | — | — |
| 1O41 | Crystal structure of SH2 in complex with RU78300. | x-ray diffraction | A | — | — |
| 1O41 | Crystal structure of SH2 in complex with RU78300. | x-ray diffraction | A | — | — |
| 1O42 | Crystal structure of SH2 in complex with RU81843. | x-ray diffraction | A | — | — |
| 1O42 | Crystal structure of SH2 in complex with RU81843. | x-ray diffraction | A | — | — |
| 1O43 | Crystal structure of SH2 in complex with RU82129. | x-ray diffraction | A | — | — |
| 1O43 | Crystal structure of SH2 in complex with RU82129. | x-ray diffraction | A | — | — |
| 1O44 | Crystal structure of sh2 in complex with ru85052 | x-ray diffraction | A | — | — |
| 1O44 | Crystal structure of SH2 in complex with RU85052 | x-ray diffraction | A | — | — |
| 1O45 | Crystal structure of SH2 in complex with RU84687. | x-ray diffraction | A | — | — |
| 1O45 | Crystal structure of SH2 in complex with RU84687. | x-ray diffraction | A | — | — |
| 1O46 | Crystal structure of SH2 in complex with RU90395. | x-ray diffraction | A | — | — |
| 1O46 | Crystal structure of SH2 in complex with RU90395. | x-ray diffraction | A | — | — |
| 1O47 | Crystal structure of SH2 in complex with RU82209. | x-ray diffraction | A | — | — |
| 1O47 | Crystal structure of SH2 in complex with RU82209. | x-ray diffraction | A | — | — |
| 1O48 | Crystal structure of SH2 in complex with RU85053. | x-ray diffraction | A | — | — |
| 1O48 | Crystal structure of SH2 in complex with RU85053. | x-ray diffraction | A | — | — |
| 1O49 | Crystal structure of SH2 in complex with RU85493. | x-ray diffraction | A | — | — |
| 1O49 | Crystal structure of SH2 in complex with RU85493. | x-ray diffraction | A | — | — |
| 1O4A | Crystal structure of SH2 in complex with RU82197. | x-ray diffraction | A | — | — |
| 1O4A | Crystal structure of SH2 in complex with RU82197. | x-ray diffraction | A | — | — |
| 1O4B | Crystal structure of SH2 in complex with RU83876. | x-ray diffraction | A | — | — |
| 1O4B | Crystal structure of SH2 in complex with RU83876. | x-ray diffraction | A | — | — |
| 1O4C | Crystal structure of SH2 in complex with phosphate. | x-ray diffraction | A | — | — |
| 1O4C | Crystal structure of SH2 in complex with phosphate. | x-ray diffraction | A | — | — |
| 1O4D | Crystal structure of SH2 in complex with RU78262. | x-ray diffraction | A | — | — |
| 1O4D | Crystal structure of SH2 in complex with RU78262. | x-ray diffraction | A | — | — |
| 1O4E | Crystal structure of SH2 in complex with RU78299. | x-ray diffraction | A | — | — |
| 1O4E | Crystal structure of SH2 in complex with RU78299. | x-ray diffraction | A | — | — |
| 1O4F | Crystal structure of SH2 in complex with RU79073. | x-ray diffraction | A | — | — |
| 1O4F | Crystal structure of SH2 in complex with RU79073. | x-ray diffraction | A | — | — |
| 1O4G | Crystal structure of SH2 in complex with DPI59. | x-ray diffraction | A | — | — |
| 1O4G | Crystal structure of SH2 in complex with DPI59. | x-ray diffraction | A | — | — |
| 1O4H | Crystal structure of SH2 in complex with RU79072. | x-ray diffraction | A | — | — |
| 1O4H | Crystal structure of SH2 in complex with RU79072. | x-ray diffraction | A | — | — |
| 1O4I | Crystal structure of SH2 in complex with PAS219. | x-ray diffraction | A | — | — |
| 1O4I | Crystal structure of SH2 in complex with PAS219. | x-ray diffraction | A | — | — |
| 1O4J | Crystal structure of SH2 in complex with ISO24. | x-ray diffraction | A | — | — |
| 1O4J | Crystal structure of SH2 in complex with ISO24. | x-ray diffraction | A | — | — |
70 records more on the page itself.
Ligands
- 6H3 · N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl) phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide · in 2 records
- ZN · Zinc ion · in 2 records
- 0LI · 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl) phenyl}benzamide · in 1 record
- HVY · N-(2-chloro-6-methylphenyl)-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4-{[2-(propanoylamino) phenyl]amino}pyrimidine-5-carboxamide · in 1 record
- L1N · 4-[(~{E})-(7-oxidanyl-6~{H}-pyrrolo[2,3-g][1,3]benzothiazol-8-yl)methylideneamino]-~{N}-pyridin-2-yl-benzenesulfonamide · in 1 record
- UCW · Tert-butyl (4-(4-amino-1-(2-(4-(dimethylamino) piperidin-1-yl)ethyl)-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)carbamate · in 1 record
Elsewhere
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