Research workbench
Crystal structures of drosophila cryptochrome
Analyse Crystal structures of drosophila cryptochrome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JZY
- Type
- protein
- Length
- 1,070 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptochrome-1
- UniProt
- O77059
- Ligands
- FAD, NA, NH4
- Pockets
- 7 · best druggability 0.87
Structure
x-ray diffraction · 2 distinct chains · 49% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptochrome-1 | protein | 534 | 48% helix, 7% strand | O77059 |
| B | Cryptochrome-1 | protein | 536 | 50% helix, 7% strand | O77059 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
- NA · Sodium ion · metal · chains B
- NH4 · Ammonium ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 618 | 0.87 | 0.92 | 67 | FAD |
| 2 | 597 | 0.87 | 0.92 | 61 | FAD, NA |
| 3 | 130 | 0.55 | 0.82 | 16 | empty |
| 4 | 122 | 0.52 | 0.81 | 16 | empty |
| 5 | 103 | 0.45 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1571 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O77059
- Elsewhere: RCSB PDB 4JZY · PDBe 4JZY · UniProt O77059
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