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Structural basis for angiopoietin-1 mediated signaling initiation

Analyse Structural basis for angiopoietin-1 mediated signaling initiation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4JYO
Type: protein
Length: 217 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Angiopoietin-1
UniProt: Q15389
Ligands: CA
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 13% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
X	Angiopoietin-1	protein	217	13% helix, 31% strand	Q15389

Ligands and binding sites

CA · Calcium ion · metal · chains X

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	71	0.36	0.77	18	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4JYO · Structural basis for angiopoietin-1 mediated signaling initiation · the same entry in another collection · chain X against X, TM-score 1.00
Q15389 · AlphaFold monomer V2.0 prediction for angiopoietin-1 (Q15389) · a predicted model of the same protein · chain X against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15389
Elsewhere: RCSB PDB 4JYO · PDBe 4JYO · UniProt Q15389

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