Research workbench
Complex structure of AML1-eto NHR2 domain with heb fragment
Analyse Complex structure of AML1-eto NHR2 domain with heb fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JOL
- Type
- protein
- Length
- 285 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein CBFA2T1; Transcription factor 12
- UniProt
- Q06455, Q99081
Structure
x-ray diffraction · 3 distinct chains · 61% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Protein CBFA2T1 | protein | 60 | 85% helix, 0% strand | Q06455 |
| E, F, G | Transcription factor 12 | protein | 11 | 0% helix, 0% strand | Q99081 |
| H | Transcription factor 12 | protein | 12 | 0% helix, 0% strand | Q99081 |
Interfaces
14 interfaces between chains.
- C–D · 1161 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1112 Ų buried · 18 hydrogen bonds · protein-protein
- B–D · 1101 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 1092 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 662 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4JOL · Complex structure of AML1-ETO NHR2 domain with HEB fragment · the same entry in another collection · chain H against H, TM-score 1.00
- Q06455 · AlphaFold monomer V2.0 prediction for protein CBFA2T1 (Q06455) · a predicted model of the same protein · chain A against A, TM-score 0.83
- Q99081 · AlphaFold monomer V2.0 prediction for transcription factor 12 (Q99081) · a predicted model of the same protein · chain H against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06455
- Every structure of UniProt Q99081
- Elsewhere: RCSB PDB 4JOL · PDBe 4JOL · UniProt Q06455 · UniProt Q99081
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