Research workbench
HIV-1 integrase catalytic core domain A128T mutant complexed with allosteric inhibitor
Analyse HIV-1 integrase catalytic core domain A128T mutant complexed with allosteric… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4JLH
- Type
- protein
- Length
- 140 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HIV-1 integrase catalytic core domain
- UniProt
- P12497
- Ligands
- 0L9, SO4
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HIV-1 integrase catalytic core domain | protein | 140 | 50% helix, 23% strand | P12497 |
Ligands and binding sites
- 0L9 · (2S)-[6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-yl](methoxy)ethanoic acid · ligand · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 4JLH · HIV-1 Integrase Catalytic Core Domain A128T Mutant Complexed with Allosteric Inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12497
- Elsewhere: RCSB PDB 4JLH · PDBe 4JLH · UniProt P12497
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