UniProt P12497
Lamina-associated polypeptide 2, isoform alpha,Integrase chimera (P12497)
Lamina-associated polypeptide 2, isoform alpha,Integrase chimera (UniProt P12497), EC 2.7.7.-, 3.1.-.-: 218 experimental structures on GenesisL1, 19 ligands bound, 223 pockets. Binding sites, pockets, druggability and 3D…
- UniProt
- P12497
- Protein
- Lamina-associated polypeptide 2, isoform alpha,Integrase chimera
- EC
- 2.7.7.-, 3.1.-.-
- Experimental structures
- 218
- Predicted models
- 0
- Ligands
- 19
- Pockets
- 223 · 16 records with a druggable one
Structures
218 records of P12497 in the MolNFT archive: 218 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A43 | Structure of the HIV-1 capsid protein dimerization domain at 2.6A resolution | x-ray diffraction | A | — | — |
| 1A43 | Structure of the HIV-1 capsid protein dimerization domain at 2.6A resolution | x-ray diffraction | A | — | — |
| 1A8O | HIV capsid C-terminal domain | x-ray diffraction | A | — | — |
| 1A8O | HIV capsid C-terminal domain | x-ray diffraction | A | — | — |
| 1AFV | HIV-1 capsid protein (P24) complex with FAB25.3 | x-ray diffraction | A, B | — | — |
| 1AFV | HIV-1 capsid protein (P24) complex with FAB25.3 | x-ray diffraction | A, B | — | — |
| 1AK4 | Human cyclophilin a bound to the amino-terminal domain of HIV-1 capsid | x-ray diffraction | C, D | — | — |
| 1AK4 | Human cyclophilin a bound to the amino-terminal domain of HIV-1 capsid | x-ray diffraction | C, D | — | — |
| 1AUM | HIV capsid C-terminal domain (CAC146) | x-ray diffraction | A | — | — |
| 1AUM | HIV capsid C-terminal domain (CAC146) | x-ray diffraction | A | — | — |
| 1B92 | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1B92 | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1B9D | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1B9D | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1B9F | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1B9F | Mobility of an HIV-1 integrase active site loop is correlated with catalytic activity | x-ray diffraction | A | — | — |
| 1BAJ | HIV-1 capsid protein C-terminal fragment plus gag P2 domain | x-ray diffraction | A | — | — |
| 1BAJ | HIV-1 capsid protein C-terminal fragment plus gag P2 domain | x-ray diffraction | A | — | — |
| 1BHL | Cacodylated catalytic domain of HIV-1 integrase | x-ray diffraction | A | — | — |
| 1BHL | Cacodylated catalytic domain of HIV-1 integrase | x-ray diffraction | A | — | — |
| 1BI4 | Catalytic domain of HIV-1 integrase | x-ray diffraction | A, B, C | — | — |
| 1BI4 | Catalytic domain of HIV-1 integrase | x-ray diffraction | A, B, C | — | — |
| 1BIS | HIV-1 integrase core domain | x-ray diffraction | A, B | — | — |
| 1BIS | HIV-1 integrase core domain | x-ray diffraction | A, B | — | — |
| 1BIU | HIV-1 integrase core domain complexed with mg++ | x-ray diffraction | A, B, C | — | — |
| 1BIU | HIV-1 integrase core domain complexed with mg++ | x-ray diffraction | A, B, C | — | — |
| 1BL3 | Catalytic domain of HIV-1 integrase | x-ray diffraction | A, B, C | — | — |
| 1BL3 | Catalytic domain of HIV-1 integrase | x-ray diffraction | A, B, C | — | — |
| 1ITG | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl… | x-ray diffraction | A | — | — |
| 1ITG | Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl… | x-ray diffraction | A | — | — |
| 1WJB | Solution structure of the N-terminal zn binding domain of HIV-1 integrase (D form), NMR, 40… | solution nmr | A, B | — | — |
| 1WJB | Solution structure of the N-terminal zn binding domain of HIV-1 integrase (D form), NMR, 40… | solution nmr | A, B | — | — |
| 1WJD | Solution structure of the N-terminal zn binding domain of HIV-1 integrase (E form), NMR, 38… | solution nmr | A, B | — | — |
| 1WJD | Solution structure of the N-terminal zn binding domain of HIV-1 integrase (E form), NMR, 38… | solution nmr | A, B | — | — |
| 2B4J | Structural basis for the recognition between HIV-1 integrase and LEDGF/p75 | x-ray diffraction | A, B | — | — |
| 2B4J | Structural basis for the recognition between HIV-1 integrase and LEDGF/P75 | x-ray diffraction | A, B | — | — |
| 2GOL | Xray Structure of Gag278 | x-ray diffraction | A, B, D | — | — |
| 2GOL | Xray structure of GAG278 | x-ray diffraction | A, B, D | — | — |
| 2GON | Xray Structure of Gag133-278 | x-ray diffraction | A, B, C, D | — | — |
| 2GON | Xray structure of GAG133-278 | x-ray diffraction | A, B, C, D | — | — |
| 2H3F | Solution structure of the HIV-1 MA protein | solution nmr | A | — | — |
| 2H3F | Solution structure of the HIV-1 ma protein | solution nmr | A | — | — |
| 2H3I | Solution structure of the HIV-1 myristoylated Matrix protein | solution nmr | A | — | — |
| 2H3I | Solution structure of the HIV-1 myristoylated matrix protein | solution nmr | A | — | — |
| 2H3Q | Solution structure of HIV-1 myrMA bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | solution nmr | A | — | — |
| 2H3Q | Solution structure of HIV-1 myrma bound to di-C4-phosphatidylinositol- (4,5)-bisphosphate | solution nmr | A | — | — |
| 2H3V | Structure of the HIV-1 Matrix protein bound to di-C8-phosphatidylinositol-(4,5)-bisphosphate | solution nmr | A | — | — |
| 2H3V | Structure of the HIV-1 matrix protein bound to di-C8- phosphatidylinositol-(4,5)-bisphosphate | solution nmr | A | — | — |
| 2H3Z | Structure of the HIV-1 matrix protein bound to di-C4-phosphatidylinositol-(4,5)-bisphosphate | solution nmr | A | — | — |
| 2H3Z | Structure of the HIV-1 matrix protein bound to di-C4- phosphatidylinositol-(4,5)-bisphosphate | solution nmr | A | — | — |
| 2HMX | Human immunodeficiency virus type 1 matrix protein | solution nmr | A | — | — |
| 2HMX | Human immunodeficiency virus type 1 matrix protein | solution nmr | A | — | — |
| 2HVP | Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1 | x-ray diffraction | A | — | — |
| 2HVP | Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1 | x-ray diffraction | A | — | — |
| 2ITG | Catalytic domain of HIV-1 integrase: ordered active site in the F185H construct | x-ray diffraction | A | — | — |
| 2ITG | Catalytic domain of HIV-1 integrase: ordered active site in the F185H construct | x-ray diffraction | A | — | — |
| 2JPR | Joint refinement of the HIV-1 CA-NTD in complex with the assembly inhibitor CAP-1 | solution nmr | A | — | — |
| 2JPR | Joint refinement of the HIV-1 ca-ntd in complex with the assembly inhibitor cap-1 | solution nmr | A | — | — |
| 2JYG | Solution Structure of the W184A/M185A Mutant of the Carboxy-terminal Dimerization Domain of the… | solution nmr | A | — | — |
| 2JYG | Solution structure of the W184A/M185A mutant of the carboxy-terminal dimerization domain of the… | solution nmr | A | — | — |
158 records more on the page itself.
Ligands
- MG · Magnesium ion · in 10 records
- SO4 · Sulfate ion · in 7 records
- ZN · Zinc ion · in 6 records
- DLU · (4r,12as)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6, 8-dioxo-3,4,6,8,12,12A-hexahydro-2H-pyrido[1',2':4, 5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide · in 5 records
- FRU · beta-D-fructofuranose · in 5 records
- GLC · alpha-D-glucopyranose · in 5 records
- 940 · (2S)-2-[2-(3,4-dihydro-2H-1,4-benzoxazin-6-yl)-4-(3,4-dimethylphenyl)-3,6-dimethyl-5-(methylsulfonylamino) phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid · in 2 records
- CL · Chloride ion · in 2 records
- GZ9 · (2S)-2-[2-(cyclohexylcarbamoylamino)-3,6-dimethyl-5-(5-methyl-3,4-dihydro-2H-chromen-6-yl)pyridin-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid · in 2 records
- IHP · Inositol hexakisphosphate · in 2 records
- 8Z3 · (2S)-2-[10-fluoranyl-1,4-dimethyl-2-(4-methyl-2-oxidanyl-phenyl)-5-methylsulfonyl-6H-phenanthridin-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid · in 1 record
- A1L1W · (2~{S})-2-[7-(cycloheptylcarbamoyl)-4',5-dimethyl-spiro[1,2-dihydroindene-3,1'-cyclohexane]-4-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid · in 1 record
- EJ9 · (2S)-2-[2-(3,4-dihydro-2H-chromen-6-yl)-4-(3,4-dimethylphenyl)-3,6-dimethyl-5-(methylsulfonylamino) phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid · in 1 record
- LF0 · (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid · in 1 record
- OZ1 · 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide · in 1 record
- QD6 · (2S)-tert-butoxy{4-(4-chlorophenyl)-2,6-dimethyl-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}acetic acid · in 1 record
- U60 · (2S)-2-[3-cyclopropyl-6-methyl-2-(5-methyl-3,4-dihydro-2H-chromen-6-yl)phenyl]-2-cyclopropyloxy-ethanoic acid · in 1 record
- W2Q · (2~{S})-2-[3-cyclopropyl-2-(3,4-dihydro-2~{H}-chromen-6-yl)-6-methyl-phenyl]-2-cyclopropyloxy-ethanoic acid · in 1 record
- XBQ · Nalpha-{[4-(4-aminobenzene-1-sulfonyl)-2-oxopiperazin-1-yl]acetyl}-N-(4-methoxyphenyl)-N-methyl-L-phenylalaninamide · in 1 record
Elsewhere
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