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Crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ domain of NHERF1

Analyse Crystal structure of the chemokine receptor CXCR2 in complex with the first PDZ… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4JL7
Type: protein
Length: 91 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NA(+)/H(+) exchange regulatory cofactor nhe-RF1
UniProt: O14745
Ligands: CL
Pockets: 1 · best druggability 0.29

Structure

x-ray diffraction · 1 distinct chain · 15% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NA(+)/H(+) exchange regulatory cofactor nhe-RF1	protein	91	15% helix, 33% strand	O14745

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	50	0.29	0.75	8	empty

Compared structures

4JL7 · Crystal Structure of the Chemokine Receptor CXCR2 in Complex with the First PDZ Domain of… · the same entry in another collection · chain A against A, TM-score 1.00
O14745 · AlphaFold monomer V2.0 prediction for NA(+)/H(+) exchange regulatory cofactor nhe-RF1… · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14745
Elsewhere: RCSB PDB 4JL7 · PDBe 4JL7 · UniProt O14745

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