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Crystal structure of alpha-COP/E19 complex

Analyse Crystal structure of alpha-COP/E19 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4J8G
Type: protein
Length: 620 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coatomer subunit alpha; Membrane glycoprotein E3 GP19K
UniProt: Q96WV5
Pockets: 3 · best druggability 0.86

Structure

x-ray diffraction · 4 distinct chains · 3% helix, 55% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Coatomer subunit alpha	protein	298	0% helix, 58% strand	Q96WV5
B	Coatomer subunit alpha	protein	302	1% helix, 57% strand	Q96WV5
C	Membrane glycoprotein E3 GP19K	protein	11	64% helix, 0% strand	—
D	Membrane glycoprotein E3 GP19K	protein	9	67% helix, 0% strand	—

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	970	0.86	0.87	74	empty
2	722	0.83	0.87	55	empty
3	150	0.46	0.77	30	empty

Interfaces

4 interfaces between chains.

A–B · 474 Å² buried · 4 hydrogen bonds · protein-protein
B–C · 437 Å² buried · 16 hydrogen bonds · protein-protein
A–D · 411 Å² buried · 14 hydrogen bonds · protein-protein
B–D · 228 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

4J8G · Crystal structure of alpha-COP/E19 complex · the same entry in another collection · chain A against A, TM-score 1.00
Q96WV5 · AlphaFold monomer V2.0 prediction for putative coatomer subunit alpha (Q96WV5) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96WV5
Elsewhere: RCSB PDB 4J8G · PDBe 4J8G · UniProt Q96WV5

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