Research workbench
Crystal structure of a fusion protein containing the nbd of HSP70 and the middle domain of hip
Analyse Crystal structure of a fusion protein containing the nbd of HSP70 and the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4J8F
- Type
- protein
- Length
- 551 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock 70 kda protein 1A/1B, HSC70-interacting protein
- UniProt
- P08107, P50503
- Ligands
- ADP, MG, IOD, PO4
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 50% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock 70 kda protein 1A/1B, HSC70-interacting protein | protein | 551 | 50% helix, 19% strand | P08107, P50503 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · chains A
- IOD · Iodide ion · ion · 17 copies · chains A
- PO4 · Phosphate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 647 | 0.77 | 0.83 | 69 | ADP, MG, PO4, IOD |
| 2 | 596 | 0.65 | 0.76 | 62 | IOD |
| 3 | 152 | 0.54 | 0.81 | 20 | IOD |
| 4 | 93 | 0.44 | 0.79 | 20 | empty |
| 5 | 94 | 0.34 | 0.74 | 17 | empty |
Compared structures
- 4J8F · Crystal structure of a fusion protein containing the NBD of Hsp70 and the middle domain… · the same entry in another collection · chain A against A, TM-score 1.00
- P50503 · AlphaFold monomer V2.0 prediction for HSC70-interacting protein (P50503) · a predicted model of the same protein · chain A against A, TM-score 0.34
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08107
- Every structure of UniProt P50503
- Elsewhere: RCSB PDB 4J8F · PDBe 4J8F · UniProt P08107 · UniProt P50503
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