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Neurolysin (endopeptidase 24.16) crystal structure

Analyse Neurolysin (endopeptidase 24.16) crystal structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1I1I
Type: protein
Length: 665 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neurolysin
EC: 3.4.24.16
UniProt: P42676
Ligands: ZN
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 59% helix, 7% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
P	Neurolysin (EC 3.4.24.16)	protein	665	59% helix, 7% strand	P42676

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1032	0.75	0.77	88	empty
2	835	0.74	0.79	83	empty
3	69	0.42	0.81	18	empty

Compared structures

1I1I · Neurolysin (endopeptidase 24.16) crystal structure · the same entry in another collection · chain P against P, TM-score 1.00
P42676 · AlphaFold monomer V2.0 prediction for neurolysin, mitochondrial (P42676) · a predicted model of the same protein · chain P against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P42676
Elsewhere: RCSB PDB 1I1I · PDBe 1I1I · UniProt P42676

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