Research workbench
Crystal structure of HCV NS5B polymerase in complex with 2,4,5- trichloro-N-(5-methyl-1,2-oxazol-3-YL)BENZENESULFONAMIDE
Analyse Crystal structure of HCV NS5B polymerase in complex with 2,4,5… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4IZ0
- Type
- protein
- Length
- 1,117 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA-directed RNA polymerase
- EC
- 2.7.7.48
- UniProt
- O92972
- Ligands
- 2BI
- Pockets
- 14 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | RNA-directed RNA polymerase (EC 2.7.7.48) | protein | 559 | 49% helix, 15% strand | O92972 |
| B | RNA-directed RNA polymerase (EC 2.7.7.48) | protein | 558 | 48% helix, 15% strand | O92972 |
Ligands and binding sites
- 2BI · 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1143 | 0.80 | 0.81 | 80 | empty |
| 2 | 1033 | 0.79 | 0.81 | 82 | 2BI |
| 3 | 106 | 0.54 | 0.83 | 19 | empty |
| 4 | 119 | 0.45 | 0.78 | 23 | empty |
| 5 | 116 | 0.44 | 0.78 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 1014 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 4IZ0 · Crystal structure of HCV NS5B polymerase in complex with… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O92972
- Elsewhere: RCSB PDB 4IZ0 · PDBe 4IZ0 · UniProt O92972
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