Research workbench
Structure of the NPP2AC-ALPHA4 complex
Analyse Structure of the NPP2AC-ALPHA4 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4IYP
- Type
- protein
- Length
- 324 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin-binding protein 1; SERINE/THREONINE-protein phosphatase 2A catalytic…
- EC
- 3.1.3.16
- UniProt
- P78318, P67775
- Pockets
- 6 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Immunoglobulin-binding protein 1 | protein | 205 | 71% helix, 0% strand | P78318 |
| C | SERINE/THREONINE-protein phosphatase 2A catalytic subunit alpha isoform (EC 3.1.3.16) | protein | 119 | 52% helix, 10% strand | P67775 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 630 | 0.77 | 0.83 | 67 | empty |
| 2 | 258 | 0.51 | 0.74 | 30 | empty |
| 3 | 167 | 0.50 | 0.77 | 20 | empty |
| 4 | 126 | 0.41 | 0.75 | 16 | empty |
| 5 | 53 | 0.37 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–C · 978 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered).
Compared structures
- 4IYP · structure of the nPP2Ac-alpha4 complex · the same entry in another collection · chain A against A, TM-score 1.00
- P78318 · AlphaFold monomer V2.0 prediction for immunoglobulin-binding protein 1 (P78318) · a predicted model of the same protein · chain A against A, TM-score 0.92
- P67775 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein phosphatase 2A catalytic… · a predicted model of the same protein · chain C against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78318
- Every structure of UniProt P67775
- Elsewhere: RCSB PDB 4IYP · PDBe 4IYP · UniProt P78318 · UniProt P67775
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