Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y- N754S) in complex with glutamate and me-CX516 at 1.72 a resolution

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Ligands and binding sites

• MQS · [(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone · ligand · 2 copies · chains A
• MQR · [(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone · ligand · chains A
• GLU · Glutamic acid · ligand · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

• 4IY6 · Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
• P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 4IY6 · PDBe 4IY6 · UniProt P19491