Research workbench
Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors
Analyse Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4IS8
- Type
- protein
- Length
- 460 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear receptor subfamily 5 group a member 2
- UniProt
- O00482
- Pockets
- 9 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 67% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Nuclear receptor subfamily 5 group a member 2 | protein | 230 | 67% helix, 3% strand | O00482 |
Pockets
9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 344 | 0.86 | 0.95 | 34 | empty |
| 2 | 278 | 0.85 | 0.96 | 31 | empty |
| 3 | 226 | 0.67 | 0.84 | 29 | empty |
| 4 | 132 | 0.66 | 0.88 | 22 | empty |
| 5 | 254 | 0.50 | 0.74 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 234 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 4IS8 · Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors · the same entry in another collection · chain A against A, TM-score 1.00
- O00482 · AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 5 group a member 2… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00482
- Elsewhere: RCSB PDB 4IS8 · PDBe 4IS8 · UniProt O00482
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