UniProt O00482
Nuclear receptor subfamily 5 group A member 2 (O00482)
Nuclear receptor subfamily 5 group A member 2 (UniProt O00482): 45 experimental structures on GenesisL1, 12 ligands bound, 22 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O00482
- Protein
- Nuclear receptor subfamily 5 group A member 2
- Experimental structures
- 45
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 22 · 5 records with a druggable one
Structures
45 records of O00482 in the MolNFT archive: 45 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1YOK | crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol | x-ray diffraction | A | — | — |
| 1YOK | Crystal structure of human lrh-1 bound with tif-2 peptide and phosphatidylglycerol | x-ray diffraction | A | — | — |
| 1YUC | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to Phospholipid and a Fragment of… | x-ray diffraction | A, B | — | — |
| 1YUC | Human nuclear receptor liver receptor homologue-1, lrh-1, bound to phospholipid and a fragment of… | x-ray diffraction | A, B | — | — |
| 1ZDU | The Crystal Structure of Human Liver Receptor Homologue-1 | x-ray diffraction | A | — | — |
| 1ZDU | The crystal structure of human liver receptor homologue-1 | x-ray diffraction | A | — | — |
| 2A66 | Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the… | x-ray diffraction | A | — | — |
| 2A66 | Human liver receptor homologue DNA-binding domain (hlrh-1 dbd) in complex with dsdna from the… | x-ray diffraction | A | — | — |
| 3TX7 | Crystal structure of LRH-1/beta-catenin complex | x-ray diffraction | B | — | — |
| 3TX7 | Crystal structure of lrh-1/BETA-catenin complex | x-ray diffraction | B | — | — |
| 4DOR | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, in its apo State Bound to a Fragment of… | x-ray diffraction | A, B | — | — |
| 4DOR | Human nuclear receptor liver receptor homologue-1, lrh-1, in its apo state bound to a fragment of… | x-ray diffraction | A, B | — | — |
| 4DOS | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to DLPC and a Fragment of TIF-2 | x-ray diffraction | A | — | — |
| 4DOS | Human nuclear receptor liver receptor homologue-1, lrh-1, bound to dlpc and a fragment of tif-2 | x-ray diffraction | A | — | — |
| 4IS8 | Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors | x-ray diffraction | A, B | — | — |
| 4IS8 | Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors | x-ray diffraction | A, B | — | — |
| 4ONI | Structure of Human Orphan Receptor LRH1 bound to two bacterial phospholipids | x-ray diffraction | A, B | — | — |
| 4ONI | Structure of human orphan receptor LRH1 bound to two bacterial phospholipids | x-ray diffraction | A, B | — | — |
| 4PLD | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, in its apo State Bound to a Fragment of… | x-ray diffraction | A | — | — |
| 4PLD | Human nuclear receptor liver receptor homologue-1, lrh-1, in its apo state bound to a fragment of… | x-ray diffraction | A | — | — |
| 4PLE | Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, Bound to an E. Coli Phospholipid and a… | x-ray diffraction | A, C, E, G | — | — |
| 4PLE | Human nuclear receptor liver receptor homologue-1, lrh-1, bound to an E. COLI phospholipid and a… | x-ray diffraction | A, C, E, G | — | — |
| 4RWV | Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in… | x-ray diffraction | A | — | — |
| 4RWV | Crystal structure of PIP3 bound human nuclear receptor lrh-1 (liver receptor homolog 1, NR5A2) in… | x-ray diffraction | A | — | — |
| 5L0M | hLRH-1 DNA Binding Domain - 12bp Oct4 promoter complex | x-ray diffraction | A | ZN | 2 (best 0.38) |
| 5L0M | Hlrh-1 DNA binding domain - 12BP OCT4 promoter complex | x-ray diffraction | A | ZN | — |
| 5L11 | Human Liver Receptor Homologue-1 (LRH-1) Bound to RJW100 and a Fragment of TIF-2 | x-ray diffraction | A | RJW | — |
| 5L11 | Human liver receptor homologue-1 (lrh-1) bound to RJW100 and a fragment of tif-2 | x-ray diffraction | A | RJW | — |
| 5SYZ | Human liver receptor homologue-1 (lrh-1) bound to a RJW100 stereoisomer and a fragment of tif-2 | x-ray diffraction | A | 71W | — |
| 5UNJ | Structure of human liver receptor homolog 1 in complex with PGC1A and RJW100 | x-ray diffraction | A | RJW | — |
| 6OQX | Human liver receptor homolog-1 bound to the agonist 5N and a fragment of the TIF2 coregulator | x-ray diffraction | A | N1V | — |
| 6OQY | Human LRH-1 bound to the agonist 6N and a fragment of the Tif2 coregulator | x-ray diffraction | A | N2J | 5 (best 0.85) |
| 6OQY | Human lrh-1 bound to the agonist 6N and a fragment of the TIF2 coregulator | x-ray diffraction | A | N2J | — |
| 6OR1 | Human LRH-1 bound to the agonist 2N and a fragment of the Tif2 coregulator | x-ray diffraction | A | N27 | 4 (best 0.86) |
| 6OR1 | Human lrh-1 bound to the agonist 2N and a fragment of the TIF2 coregulator | x-ray diffraction | A | N27 | — |
| 6VC2 | Lrh-1 bound to ss-RJW100 and a fragment of the TIF2 coactivator | x-ray diffraction | A | QU7 | — |
| 6VIF | Human lrh-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator tif-2 | x-ray diffraction | A | QY4 | — |
| 7JYD | Human Liver Receptor Homolog-1 in Complex with 10CA and a Fragment of Tif2 | x-ray diffraction | A | VQA | 4 (best 0.84) |
| 7JYD | Human liver receptor homolog-1 in complex with 10CA and a fragment of TIF2 | x-ray diffraction | A | VQA | — |
| 7JYE | Human Liver Receptor Homolog-1 in Complex with 9ChoP and a Fragment of Tif2 | x-ray diffraction | A | VQY | 4 (best 0.84) |
| 7JYE | Human liver receptor homolog-1 in complex with 9CHOP and a fragment of TIF2 | x-ray diffraction | A | VQY | — |
| 7TT8 | Human lrh-1 lbd bound to agonist 6N-10CA and fragment of TIF2 coactivator | x-ray diffraction | A | IUW | — |
| 8F8M | LRH-1 bound to small molecule Tet and fragment of coactivator Tif2 | x-ray diffraction | A | XKE | 3 (best 0.84) |
| 8PKI | Cryo-EM structure of NR5A2-nucleosome complex SHL+5.5 | electron microscopy | K | ZN | — |
| O00482 | AlphaFold monomer V2.0 prediction for nuclear receptor subfamily 5 group a member 2 (O00482) | — | — | — |
Ligands
- RJW · (1r,3ar,6ar)-5-hexyl-4-phenyl-3A-(1-phenylethenyl)-1,2, 3,3A,6,6A-hexahydropentalen-1-ol · in 3 records
- ZN · Zinc ion · in 3 records
- N27 · N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]acetamide · in 2 records
- N2J · N-[(1S,3aR,6aR)-5-hexyl-4-phenyl-3a-(1-phenylethenyl)-1,2,3,3a,6,6a-hexahydropentalen-1-yl]sulfuric diamide · in 2 records
- VQA · 10-[(3aR,6R,6aR)-6-hydroxy-3-phenyl-3a-(1-phenylethenyl)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid · in 2 records
- VQY · 9-[(3~{a}~{R},6~{R},6~{a}~{R})-6-oxidanyl-3-phenyl-3~{a}-(1-phenylethenyl)-4,5,6,6~{a}-tetrahydro-1~{H}-pentalen-2-yl]nonyl 2-(trimethyl-$l^{4}-azanyl)ethyl hydrogen phosphate · in 2 records
- 71W · (1s,3ar,6ar)-5-hexyl-4-phenyl-3A-(1-phenylethenyl)-1,2, 3,3A,6,6A-hexahydropentalen-1-ol · in 1 record
- IUW · 10-[(3aR,6S,6aR)-3-phenyl-3a-(1-phenylethenyl)-6-(sulfamoylamino)-1,3a,4,5,6,6a-hexahydropentalen-2-yl]decanoic acid (non-preferred name) · in 1 record
- N1V · (8beta,11alpha,12alpha)-8-(1-phenylethenyl)-1,6:7,14-dicycloprosta-1,3,5,7(14)-tetraen-11-yl sulfamate · in 1 record
- QU7 · (1s,3as,6as)-5-hexyl-4-phenyl-3A-(1-phenylethenyl)-1,2, 3,3A,6,6A-hexahydropentalen-1-ol · in 1 record
- QY4 · N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl) amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide · in 1 record
- XKE · (1~{R},3~{a}~{R},6~{a}~{R})-4-phenyl-3~{a}-(1-phenylethenyl)-5-[9-(1~{H}-1,2,3,4-tetrazol-5-yl)nonyl]-2,3,6,6~{a}-tetrahydro-1~{H}-pentalen-1-ol · in 1 record
Elsewhere
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