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Ligand · PIZ

PIZ · (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate

PIZ, (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane -1,2-diyl dihexadecanoate (C41 H82 O22 P4, 1051.0 g/mol), in the MolNFT structures on GenesisL1: bound in 4…

Component
PIZ
Formula
C41 H82 O22 P4
Class
ligand
Structures
4
PDB entries
2

Binding sites

PIZ in 4 structures; the first of them:

  • 4QJR · Crystal structure of human nuclear receptor sf-1 (nr5a1) bound to its hormone pip3 at 2.4… · PIZ A501 · binds PHE262, LEU265, CYS266, MET268, ALA269, TRP302, SER303, LEU306 and 19 more
  • 4RWV · Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1… · PIZ A601 · binds THR341, PHE342, MET345, CYS346, MET348, ALA349, TRP382, SER383 and 18 more
  • 4QJR · Crystal structure of human nuclear receptor sf-1 (NR5A1) bound to its hormone PIP3 at 2.4… · PIZ A501 · binds PHE262, LEU265, CYS266, MET268, ALA269, TRP302, SER303, LEU306 and 19 more
  • 4RWV · Crystal structure of PIP3 bound human nuclear receptor lrh-1 (liver receptor homolog 1… · PIZ A601 · binds THR341, PHE342, MET345, CYS346, MET348, ALA349, TRP382, SER383 and 18 more

Residues it binds most

LEU 4, ALA 4, VAL 4, ILE 2, MET 4, SER 4, THR 4, CYS 4, GLN 4, GLY 4 (residue and the binding sites it lines).

Found with

  • ACT · Acetate ion
  • EDO · 1,2-ethanediol
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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