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Lrr domain from human NLRP1

Analyse Lrr domain from human NLRP1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4IM6
Type: protein
Length: 198 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nacht, lrr and pyd domains-containing protein 1
UniProt: Q9C000
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nacht, lrr and pyd domains-containing protein 1	protein	198	43% helix, 12% strand	Q9C000

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	73	0.57	0.88	14	empty

Modifications

Observed in the structure: 1 modified (oxidation).

Compared structures

4IM6 · LRR domain from human NLRP1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9C000 · AlphaFold monomer V2.0 prediction for nacht, lrr and pyd domains- containing protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9C000
Elsewhere: RCSB PDB 4IM6 · PDBe 4IM6 · UniProt Q9C000

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