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Crystal structure of an PRP8P rnaseh W1911A mutant protein
Analyse Crystal structure of an PRP8P rnaseh W1911A mutant protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ILJ
- Type
- protein
- Length
- 508 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pre-mRNA-splicing factor 8
- UniProt
- P33334
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Pre-mRNA-splicing factor 8 | protein | 254 | 46% helix, 18% strand | P33334 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 560 | 0.72 | 0.81 | 58 | empty |
| 2 | 513 | 0.72 | 0.81 | 50 | empty |
| 3 | 182 | 0.61 | 0.82 | 23 | empty |
| 4 | 102 | 0.48 | 0.80 | 16 | empty |
| 5 | 58 | 0.45 | 0.83 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 979 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 4ILJ · Crystal structure of an Prp8p RNaseH W1911A mutant protein · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33334
- Elsewhere: RCSB PDB 4ILJ · PDBe 4ILJ · UniProt P33334
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