Crystal structure of truncated (delta 1-89) human methionine aminopeptidase type 1 in complex with N1-(5-chloro-6-methyl-2- (pyridin-2-YL)PYRIMIDIN-4-yl)-N2-(6-(TRIFLUOROMETHYL)PYRIDIN-2-yl) ethane-1,2-diamine

Structure

x-ray diffraction · 1 distinct chain · 27% helix, 22% strand (DSSP).

Ligands and binding sites

• TFD · N-[5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl]-N'-[6-(trifluoromethyl)pyridin-2-yl]ethane-1,2-diamine · ligand · chains A
• CO · Cobalt (II) ion · metal · 3 copies · chains A
• K · Potassium ion · metal · chains A
• GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 4IKS · Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in… · the same entry in another collection · chain A against A, TM-score 1.00
• P53582 · AlphaFold monomer V2.0 prediction for methionine aminopeptidase 1 (P53582) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P53582
• Elsewhere: RCSB PDB 4IKS · PDBe 4IKS · UniProt P53582