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Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I: structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity
Analyse Pyrrolopyrimidine inhibitors of DNA gyrase B and topoisomerase IV, part I… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HZ5
- Type
- protein
- Length
- 1,710 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- H7C794
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, F, H | — | protein | 191 | — | H7C794 |
| B, G | — | protein | 190 | — | H7C794 |
| D | — | protein | 190 | — | H7C794 |
| J | — | protein | 185 | — | H7C794 |
Compared structures
- 4HZ5 · Pyrrolopyrimidine inhibitors of dna gyrase b and topoisomerase iv, part i: structure… · the same entry in another collection · chain J against J, TM-score 1.00
- H7C794 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 4 subunit B (H7C794) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt H7C794
- Elsewhere: RCSB PDB 4HZ5 · PDBe 4HZ5 · UniProt H7C794
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