Research workbench

Crystal structure of mthk pore

Analyse Crystal structure of mthk pore in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HYO
Type: protein
Length: 656 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-gated potassium channel mthk
UniProt: O27564
Ligands: K
Pockets: 17 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Calcium-gated potassium channel mthk	protein	82	78% helix, 0% strand	O27564

Ligands and binding sites

K · Potassium ion · metal · 8 copies · chains A, B, C, D, E, F, G, H
HEZ · Hexane-1,6-diol · additive · 12 copies · chains A, F, B, C, D, E, G, H

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

17 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1034	0.75	0.77	53	empty
2	677	0.74	0.80	44	empty
3	697	0.73	0.79	44	empty
4	73	0.45	0.81	16	empty
5	131	0.44	0.75	21	empty

Interfaces

13 interfaces between chains.

E–G · 828 Å² buried · 6 hydrogen bonds · protein-protein
B–C · 824 Å² buried · 6 hydrogen bonds · protein-protein
B–D · 823 Å² buried · 6 hydrogen bonds · protein-protein
E–H · 820 Å² buried · 6 hydrogen bonds · protein-protein
A–C · 820 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

4HYO · Crystal Structure of MthK Pore · the same entry in another collection · chain H against H, TM-score 1.00
O27564 · AlphaFold monomer V2.0 prediction for calcium-gated potassium channel mthk (O27564) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O27564
Elsewhere: RCSB PDB 4HYO · PDBe 4HYO · UniProt O27564

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.