UniProt O27564
Calcium-gated potassium channel MthK (O27564)
Calcium-gated potassium channel MthK (UniProt O27564): 72 experimental structures on GenesisL1, 2 ligands bound, 40 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O27564
- Protein
- Calcium-gated potassium channel MthK
- Experimental structures
- 72
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 40 · 2 records with a druggable one
Structures
72 records of O27564 in the MolNFT archive: 72 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1LNQ | Crystal structure of mthk at 3.3 a | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 1LNQ | Crystal structure of mthk at 3.3 a | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2AEF | Crystal Structures of the MthK RCK Domain in Ca2+ bound form | x-ray diffraction | A, B | — | — |
| 2AEF | Crystal structures of the mthk rck domain in CA2+ bound form | x-ray diffraction | A, B | — | — |
| 2AEJ | Crystal Structures of the MthK RCK Domain in no Ca2+ bound form | x-ray diffraction | A, B | — | — |
| 2AEJ | Crystal structures of the mthk rck domain in no CA2+ bound form | x-ray diffraction | A, B | — | — |
| 2AEM | Crystal Structures of the MthK RCK Domain | x-ray diffraction | A | — | — |
| 2AEM | Crystal structures of the mthk rck domain | x-ray diffraction | A | — | — |
| 2FY8 | Crystal structure of MthK rck domain in its ligand-free gating-ring form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2FY8 | Crystal structure of mthk rck domain in its ligand-free gating-ring form | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 2OGU | Crystal structure of the isolated MthK RCK domain | x-ray diffraction | A | — | — |
| 2OGU | Crystal structure of the isolated mthk rck domain | x-ray diffraction | A | — | — |
| 3KXD | Crystal structure of the mthk rck in complex with cadmium | x-ray diffraction | A, B | — | — |
| 3KXD | Crystal structure of the mthk rck in complex with cadmium | x-ray diffraction | A, B | — | — |
| 3LDC | High resolution open MthK pore structure crystallized in 100 mM K+ | x-ray diffraction | A | — | — |
| 3LDC | High resolution open mthk pore structure crystallized in 100 mm K+ | x-ray diffraction | A | — | — |
| 3LDD | High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 99 mM… | x-ray diffraction | A | — | — |
| 3LDD | High resolution open mthk pore structure crystallized in 100 mm K+ and further soaked in 99 mm… | x-ray diffraction | A | — | — |
| 3LDE | High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 100 mM Na+. | x-ray diffraction | A | — | — |
| 3LDE | High resolution open mthk pore structure crystallized in 100 mm K+ and further soaked in 100 mm na+. | x-ray diffraction | A | — | — |
| 3OUS | MthK channel pore T59A mutant | x-ray diffraction | A | — | — |
| 3OUS | Mthk channel pore T59A mutant | x-ray diffraction | A | — | — |
| 3R65 | MthK channel pore E92Q mutant | x-ray diffraction | A | — | — |
| 3R65 | Mthk channel pore E92Q mutant | x-ray diffraction | A | — | — |
| 3RBX | MthK RCK domain D184N mutant, Ca2+-bound | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3RBX | Mthk rck domain D184N mutant, CA2+-bound | x-ray diffraction | A, B, C, D, E, F | — | — |
| 3RBZ | MthK channel, Ca2+-bound | x-ray diffraction | A, B, C, D | — | — |
| 3RBZ | Mthk channel, CA2+-bound | x-ray diffraction | A, B, C, D | — | — |
| 4EI2 | Crystal Structures of MthK RCK gating ring bound to Barium | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 4EI2 | Crystal structures of mthk rck gating ring bound to barium | x-ray diffraction | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P | — | — |
| 4HYO | Crystal Structure of MthK Pore | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4HYO | Crystal structure of mthk pore | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4HZ3 | MthK pore crystallized in presence of TBSb | x-ray diffraction | D, C, A, B, E, F, G, H | — | — |
| 4HZ3 | Mthk pore crystallized in presence of tbsb | x-ray diffraction | D, C, A, B, E, F, G, H | — | — |
| 4L73 | Ca2+-bound MthK RCK domain at 2.5 Angstrom | x-ray diffraction | A, B | — | — |
| 4L73 | CA2+-bound mthk rck domain at 2.5 ångström | x-ray diffraction | A, B | — | — |
| 4L74 | Ca2+-bound MthK RCK domain at 1.9 Angstrom with single ligand | x-ray diffraction | A, B | — | — |
| 4L74 | CA2+-bound mthk rck domain at 1.9 ångström with single ligand | x-ray diffraction | A, B | — | — |
| 4L75 | Ca2+-bound D184N mutant MthK RCK domain at 2.4 Angstrom | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4L75 | CA2+-bound D184N mutant mthk rck domain at 2.4 ångström | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4L76 | Ca2+-bound E212Q mutant MthK RCK domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4L76 | CA2+-bound E212Q mutant mthk rck domain | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4QE7 | Open MthK pore structure soaked in 10 mM Ba2+/100 mM Na+ | x-ray diffraction | A | — | — |
| 4QE7 | Open mthk pore structure soaked in 10 mm BA2+/100 mm na+ | x-ray diffraction | A | — | — |
| 4QE9 | Open MthK pore structure soaked in 10 mM Ba2+/100 mM K+ | x-ray diffraction | A | — | — |
| 4QE9 | Open mthk pore structure soaked in 10 mm BA2+/100 mm K+ | x-ray diffraction | A | — | — |
| 4RO0 | Crystal structure of MthK gating ring in a ligand-free form | x-ray diffraction | A, a, B, b, C, c, D, d, E, e, F, f, G, g, H, h, I, i, J, j, K, k, L, l, M, m, N, n, O, o, P, p, Q, q, R, r, S, s, T, t | — | — |
| 4RO0 | Crystal structure of mthk gating ring in a ligand-free form | x-ray diffraction | A, a, B, b, C, c, D, d, E, e, F, f, G, g, H, h, I, i, J, j, K, k, L, l, M, m, N, n, O, o, P, p, Q, q, R, r, S, s, T, t | — | — |
| 5BKK | bbTBA-bound closed MthK channel in nanodisc | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 6OLY | Full-length mthk channel at 3.1 ångström resolution | x-ray diffraction | A, B, C, D | CA | — |
| 6U5N | Calcium-bound mthk gating ring state 2 | electron microscopy | A, E, B, F, C, G, D, H | CA | — |
| 6U5P | Calcium-bound MthK gating ring state 1 | electron microscopy | A, E, B, F, C, G, D, H | CA | 20 (best 0.72) |
| 6U5P | Calcium-bound mthk gating ring state 1 | electron microscopy | A, E, B, F, C, G, D, H | CA | — |
| 6U5R | Calcium-bound mthk closed state | electron microscopy | A, B, C, D, E, F, G, H | CA | — |
| 6U68 | Calcium-bound mthk open-inactivated state 1 | electron microscopy | A, B, C, D, E, F, G, H | — | — |
| 6U6D | Mthk closed state with edta | electron microscopy | A, C, E, G, B, D, F, H | K | — |
| 6U6E | Calcium-bound mthk open-inactivated state 2 | electron microscopy | A, D, B, C, H, G, F, E | — | — |
| 6U6H | Calcium-bound mthk open-inactivated state 3 | electron microscopy | A, C, B, D, H, G, F, E | — | — |
| 6U9P | Wild-type mthk pore in ~150 mm K+ | x-ray diffraction | A | K | — |
| 6U9T | Wild-type MthK pore in 50 mM K+ | x-ray diffraction | A | K | — |
12 records more on the page itself.
Ligands
Elsewhere
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