Research workbench
Human immunodeficiency virus type 1 reverse transcriptase complexed with a 33-base nucleotide RNA pseudoknot
Analyse Human immunodeficiency virus type 1 reverse transcriptase complexed with a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HVU
- Type
- protein + RNA
- Length
- 3,936 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- RNA (33 nucleotide RNA pseudoknot); Protein (HIV-1 reverse transcriptase)
- EC
- 2.7.7.49
- UniProt
- P03366
- Pockets
- 20 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 34% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C, F, I, L | RNA (33 nucleotide RNA pseudoknot) | rna | 30 | — | — |
| A, D, G, J | Protein (HIV-1 reverse transcriptase) (EC 2.7.7.49) | protein | 554 | 32% helix, 22% strand | P03366 |
| B, E, H, K | Protein (HIV-1 reverse transcriptase) (EC 2.7.7.49) | protein | 400 | 36% helix, 18% strand | P03366 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 989 | 0.82 | 0.83 | 114 | empty |
| 2 | 986 | 0.81 | 0.82 | 118 | empty |
| 3 | 705 | 0.79 | 0.84 | 112 | empty |
| 4 | 677 | 0.77 | 0.82 | 89 | empty |
| 5 | 629 | 0.77 | 0.83 | 82 | empty |
Interfaces
15 interfaces between chains.
- G–H · 1290 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 1288 Ų buried · 10 hydrogen bonds · protein-protein
- J–K · 1288 Ų buried · 10 hydrogen bonds · protein-protein
- D–E · 1281 Ų buried · 10 hydrogen bonds · protein-protein
- I–G · 433 Ų buried · 1 hydrogen bond · protein-nucleic
Compared structures
- 1HVU · Human immunodeficiency virus type 1 reverse transcriptase complexed with a 33-base… · the same entry in another collection · chain C against C, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 1HVU · PDBe 1HVU · UniProt P03366
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.