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Crystal structure of rhodobacter sphaeroides lov protein

Analyse Crystal structure of rhodobacter sphaeroides lov protein in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4HNB
Type: protein
Length: 353 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lov protein
Ligands: FMN, FNR
Pockets: 5 · best druggability 0.76

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lov protein	protein	176	45% helix, 21% strand	—
B	Lov protein	protein	177	48% helix, 21% strand	—

Ligands and binding sites

FMN · Flavin mononucleotide · ligand · chains A
FNR · 1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydro-2H-benzo[g]pteridin-1-id-10(5H)-yl)-5-O-phosphonato-D-ribitol · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	166	0.76	0.92	23	FMN
2	174	0.75	0.91	24	FNR
3	116	0.59	0.86	21	empty
4	71	0.50	0.85	20	empty
5	82	0.36	0.77	25	empty

Interfaces

1 interface between chains.

A–B · 1177 Å² buried · 12 hydrogen bonds · protein-protein

Compared structures

4HNB · Crystal Structure of Rhodobacter Sphaeroides LOV protein · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 4HNB · PDBe 4HNB

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