Research workbench
Crystal structure of the human gipr ecd in complex with GIPG013 Fab at 3-a resolution
Analyse Crystal structure of the human gipr ecd in complex with GIPG013 Fab at 3-a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4HJ0
- Type
- protein
- Length
- 1,015 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gastric inhibitory polypeptide receptor; GIPG013 Fab, antagonizing antibody to the gip…
- UniProt
- P48546
- Pockets
- 18 · best druggability 0.69
Structure
x-ray diffraction · 6 distinct chains · 8% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gastric inhibitory polypeptide receptor | protein | 92 | 24% helix, 25% strand | P48546 |
| B | Gastric inhibitory polypeptide receptor | protein | 91 | 26% helix, 14% strand | P48546 |
| P | GIPG013 Fab, antagonizing antibody to the gip receptor, heavy chain | protein | 206 | 1% helix, 47% strand | — |
| Q | GIPG013 Fab, antagonizing antibody to the gip receptor, light chain | protein | 210 | 4% helix, 43% strand | — |
| D | GIPG013 Fab, antagonizing antibody to the gip receptor, light chain | protein | 211 | 6% helix, 33% strand | — |
| C | GIPG013 Fab, antagonizing antibody to the gip receptor, heavy chain | protein | 205 | 3% helix, 47% strand | — |
Pockets
18 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 60 | 0.69 | 0.96 | 17 | empty |
| 2 | 286 | 0.59 | 0.78 | 41 | empty |
| 3 | 426 | 0.57 | 0.74 | 40 | empty |
| 4 | 100 | 0.49 | 0.81 | 21 | empty |
| 5 | 228 | 0.48 | 0.74 | 39 | empty |
Interfaces
9 interfaces between chains.
- P–Q · 1617 Ų buried · 18 hydrogen bonds · protein-protein
- D–C · 1571 Ų buried · 14 hydrogen bonds · protein-protein
- A–P · 747 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 746 Ų buried · 7 hydrogen bonds · protein-protein
- P–C · 665 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 disulfide (disulfide).
Compared structures
- 4HJ0 · Crystal structure of the human GIPr ECD in complex with Gipg013 Fab at 3-A resolution · the same entry in another collection · chain B against B, TM-score 1.00
- P48546 · AlphaFold monomer V2.0 prediction for gastric inhibitory polypeptide receptor (P48546) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P48546
- Elsewhere: RCSB PDB 4HJ0 · PDBe 4HJ0 · UniProt P48546
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