Research workbench
Structure of MUTS139F P73 DNA binding domain complexed with 20BP DNA response element
Analyse Structure of MUTS139F P73 DNA binding domain complexed with 20BP DNA response… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GUQ
- Type
- protein + DNA
- Length
- 418 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3'); Tumor protein P73
- UniProt
- O15350
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 13% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E, F | DNA (5'-D(P*GP*AP*AP*CP*AP*TP*GP*TP*TP*C)-3') | dna | 10 | — | — |
| A | Tumor protein P73 | protein | 200 | 13% helix, 34% strand | O15350 |
| B | Tumor protein P73 | protein | 198 | 13% helix, 32% strand | O15350 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 927 | 0.76 | 0.79 | 100 | empty |
| 2 | 55 | 0.40 | 0.81 | 19 | empty |
| 3 | 159 | 0.40 | 0.73 | 23 | empty |
| 4 | 108 | 0.38 | 0.75 | 19 | empty |
| 5 | 91 | 0.35 | 0.75 | 16 | empty |
Interfaces
6 interfaces between chains.
- E–F · 441 Ų buried · 39 hydrogen bonds · nucleic-nucleic
- F–A · 326 Ų buried · 8 hydrogen bonds · protein-nucleic
- E–B · 300 Ų buried · 6 hydrogen bonds · protein-nucleic
- A–B · 247 Ų buried · 8 hydrogen bonds · protein-protein
- E–A · 142 Ų buried · 0 hydrogen bonds · protein-nucleic
Compared structures
- 4GUQ · Structure of mutS139F p73 DNA binding domain complexed with 20BP DNA response element · the same entry in another collection · chain E against E, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15350
- Elsewhere: RCSB PDB 4GUQ · PDBe 4GUQ · UniProt O15350
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