Research workbench
Structure of unliganded, inactive ROR2 kinase domain
Analyse Structure of unliganded, inactive ROR2 kinase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GT4
- Type
- protein
- Length
- 547 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase transmembrane receptor ROR2
- EC
- 2.7.10.1
- UniProt
- Q01974
- Ligands
- NO3
- Pockets
- 3 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 274 | 40% helix, 17% strand | Q01974 |
| B | Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) | protein | 273 | 41% helix, 18% strand | Q01974 |
Ligands and binding sites
- NO3 · Nitrate ion · ion · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 466 | 0.65 | 0.77 | 37 | empty |
| 2 | 261 | 0.54 | 0.76 | 48 | empty |
| 3 | 154 | 0.52 | 0.80 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 878 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 4GT4 · Structure of unliganded, inactive Ror2 kinase domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q01974 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase transmembrane receptor ROR2… · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01974
- Elsewhere: RCSB PDB 4GT4 · PDBe 4GT4 · UniProt Q01974
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.