Research workbench

The crystal structure of human fascin 1 K358A mutant

Analyse The crystal structure of human fascin 1 K358A mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GP3
Type: protein
Length: 961 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fascin
UniProt: Q16658
Ligands: CL, BR
Pockets: 11 · best druggability 0.71

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 48% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fascin	protein	480	6% helix, 49% strand	Q16658
B	Fascin	protein	481	6% helix, 47% strand	Q16658

Ligands and binding sites

CL · Chloride ion · ion · 18 copies · chains A, B
BR · Bromide ion · ion · 7 copies · chains A, B
GOL · Glycerol · additive · 7 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	592	0.71	0.79	44	CL
2	461	0.65	0.78	66	empty
3	226	0.50	0.75	30	GOL
4	139	0.49	0.79	36	empty
5	90	0.47	0.81	17	empty

Interfaces

1 interface between chains.

A–B · 702 Å² buried · 2 hydrogen bonds · protein-protein

Compared structures

4GP3 · The crystal structure of human fascin 1 K358A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q16658 · AlphaFold monomer V2.0 prediction for fascin (Q16658) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q16658
Elsewhere: RCSB PDB 4GP3 · PDBe 4GP3 · UniProt Q16658

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.