Research workbench
Crystal structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15
Analyse Crystal structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GNF
- Type
- protein
- Length
- 105 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase NSD3; Histone H3.3
- EC
- 2.1.1.43
- UniProt
- Q9BZ95, P84243
- Ligands
- ZN
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.43) | protein | 96 | 6% helix, 19% strand | Q9BZ95 |
| C | Histone H3.3 | protein | 9 | 0% helix, 33% strand | P84243 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–C · 667 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 4GNF · Crystal Structure of NSD3 tandem PHD5-C5HCH domains complexed with H3 peptide 1-15 · the same entry in another collection · chain C against C, TM-score 1.00
- Q9BZ95 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase NSD3 (Q9BZ95) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P84243 · AlphaFold monomer V2.0 prediction for histone H3.3 (P84243) · a predicted model of the same protein · chain C against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BZ95
- Every structure of UniProt P84243
- Elsewhere: RCSB PDB 4GNF · PDBe 4GNF · UniProt Q9BZ95 · UniProt P84243
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