Research workbench
Crystal structure of the mutb F164L mutant from crystals soaked with isomaltulose
Analyse Crystal structure of the mutb F164L mutant from crystals soaked with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4GIA
- Type
- protein
- Length
- 1,110 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sucrose isomerase
- EC
- 5.4.11.99
- UniProt
- Q2PS28
- Ligands
- CA
- Pockets
- 11 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sucrose isomerase (EC 5.4.11.99) | protein | 554 | 34% helix, 19% strand | Q2PS28 |
| B | Sucrose isomerase (EC 5.4.11.99) | protein | 556 | 34% helix, 18% strand | Q2PS28 |
Ligands and binding sites
- CA · Calcium ion · metal · 2 copies · chains A, B
- GOL · Glycerol · additive · 12 copies · chains A, B
- TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 115 | 0.79 | 0.97 | 24 | GOL |
| 2 | 120 | 0.78 | 0.97 | 22 | TRS, GOL |
| 3 | 62 | 0.74 | 0.99 | 19 | empty |
| 4 | 56 | 0.73 | 0.99 | 16 | empty |
| 5 | 308 | 0.60 | 0.78 | 35 | GOL |
Interfaces
1 interface between chains.
- A–B · 229 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 4GIA · Crystal structure of the MUTB F164L mutant from crystals soaked with isomaltulose · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2PS28
- Elsewhere: RCSB PDB 4GIA · PDBe 4GIA · UniProt Q2PS28
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