Crystal structure of human gltp bound with 12:0 disulfatide (orthorombic form; two subunits in asymmetric unit)

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 1% strand (DSSP).

Ligands and binding sites

• 0SG · N-{(2S,3R,4E)-1-[(3,6-di-O-sulfo-beta-D-galactopyranosyl)oxy]-3-hydroxyoctadec-4-en-2-yl}dodecanamide · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 564 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 4GHS · Crystal structure of human GLTP bound with 12:0 disulfatide (orthorombic form; two… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9NZD2 · AlphaFold monomer V2.0 prediction for glycolipid transfer protein (Q9NZD2) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9NZD2
• Elsewhere: RCSB PDB 4GHS · PDBe 4GHS · UniProt Q9NZD2