Research workbench

Structure of a sych-yoph chaperone-effector complex

Analyse Structure of a sych-yoph chaperone-effector complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4GF3
Type: protein
Length: 151 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative yoph targeting protein; Tyrosine-protein phosphatase yoph
UniProt: Q7BTX0, P15273
Pockets: 2 · best druggability 0.38

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative yoph targeting protein	protein	123	31% helix, 29% strand	Q7BTX0
B	Tyrosine-protein phosphatase yoph	protein	28	46% helix, 29% strand	P15273

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	55	0.38	0.80	17	empty
2	60	0.35	0.76	12	empty

Interfaces

1 interface between chains.

A–B · 993 Å² buried · 13 hydrogen bonds · protein-protein

Compared structures

4GF3 · Structure of a SycH-YopH Chaperone-Effector Complex · the same entry in another collection · chain A against A, TM-score 1.00
P15273 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase yoph (P15273) · a predicted model of the same protein · chain B against A, TM-score 0.55

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7BTX0
Every structure of UniProt P15273
Elsewhere: RCSB PDB 4GF3 · PDBe 4GF3 · UniProt Q7BTX0 · UniProt P15273

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