Research workbench
Miniprotein mp-2 (M9A) complex with streptavidin
Analyse Miniprotein mp-2 (M9A) complex with streptavidin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HQQ
- Type
- protein
- Length
- 528 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Streptavidin; Mp-2
- UniProt
- P22629
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Streptavidin | protein | 119 | 8% helix, 57% strand | P22629 |
| E, F, G, H | Mp-2 | protein | 13 | 23% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 470 | 0.68 | 0.80 | 57 | empty |
| 2 | 216 | 0.56 | 0.79 | 35 | empty |
| 3 | 213 | 0.56 | 0.79 | 34 | empty |
| 4 | 108 | 0.36 | 0.73 | 27 | empty |
| 5 | 100 | 0.35 | 0.73 | 25 | empty |
Interfaces
14 interfaces between chains.
- C–D · 1629 Ų buried · 26 hydrogen bonds · protein-protein
- A–B · 1628 Ų buried · 26 hydrogen bonds · protein-protein
- B–F · 497 Ų buried · 4 hydrogen bonds · protein-protein
- C–G · 487 Ų buried · 7 hydrogen bonds · protein-protein
- A–E · 486 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1HQQ · Miniprotein mp-2 (M9A) complex with streptavidin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22629
- Elsewhere: RCSB PDB 1HQQ · PDBe 1HQQ · UniProt P22629
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