Research workbench
Human immunodeficiency virus type 1
Analyse Human immunodeficiency virus type 1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1HQE
- Type
- protein
- Length
- 969 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pol polyprotein
- EC
- 2.7.7.49
- UniProt
- P03366
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pol polyprotein (EC 2.7.7.49) | protein | 554 | 31% helix, 20% strand | P03366 |
| B | Pol polyprotein (EC 2.7.7.49) | protein | 415 | 30% helix, 18% strand | P03366 |
Pockets
13 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 918 | 0.75 | 0.78 | 84 | empty |
| 2 | 632 | 0.69 | 0.77 | 55 | empty |
| 3 | 495 | 0.67 | 0.78 | 55 | empty |
| 4 | 692 | 0.65 | 0.74 | 69 | empty |
| 5 | 443 | 0.64 | 0.78 | 40 | empty |
Interfaces
1 interface between chains.
- A–B · 2793 Ų buried · 32 hydrogen bonds · protein-protein
Compared structures
- 1HQE · Human immunodeficiency virus type 1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 1HQE · PDBe 1HQE · UniProt P03366
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