Research workbench

Crystal structure of P73 DNA-binding domain tetramer bound to a full response-element

Analyse Crystal structure of P73 DNA-binding domain tetramer bound to a full… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4G83
Type: protein + DNA
Length: 416 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA; Tumor protein P73
UniProt: O15350
Ligands: ZN
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E, F	DNA	dna	10	—	—
A, B	Tumor protein P73	protein	198	10% helix, 33% strand	O15350

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	765	0.74	0.79	73	empty
2	127	0.42	0.76	17	empty
3	127	0.39	0.74	20	empty
4	52	0.35	0.79	17	empty
5	85	0.34	0.75	16	empty

Interfaces

6 interfaces between chains.

E–F · 443 Å² buried · 34 hydrogen bonds · nucleic-nucleic
F–A · 278 Å² buried · 7 hydrogen bonds · protein-nucleic
E–B · 276 Å² buried · 8 hydrogen bonds · protein-nucleic
A–B · 236 Å² buried · 6 hydrogen bonds · protein-protein
F–B · 185 Å² buried · 2 hydrogen bonds · protein-nucleic

Compared structures

4G83 · Crystal Structure of p73 DNA-Binding Domain Tetramer bound to a Full Response-Element · the same entry in another collection · chain E against E, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O15350
Elsewhere: RCSB PDB 4G83 · PDBe 4G83 · UniProt O15350

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.