Structure complex of lgn binding with FRMPD1

Structure

x-ray diffraction · 2 distinct chains · 82% helix, 0% strand (DSSP).

Ligands and binding sites

• CL · Chloride ion · ion · chains A
• GOL · Glycerol · additive · 8 copies · chains A, B
• BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1313 Ų buried · 34 hydrogen bonds · protein-protein

Compared structures

• 4G2V · Structure complex of LGN binding with FRMPD1 · the same entry in another collection · chain A against A, TM-score 1.00
• Q8VDU0 · AlphaFold monomer V2.0 prediction for G-protein-signaling modulator 2 (Q8VDU0) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q5SYB0 · AlphaFold monomer V2.0 prediction for ferm and PDZ domain-containing protein 1 (Q5SYB0) · a predicted model of the same protein · chain B against A, TM-score 0.26

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8VDU0
• Every structure of UniProt Q5SYB0
• Elsewhere: RCSB PDB 4G2V · PDBe 4G2V · UniProt Q8VDU0 · UniProt Q5SYB0