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Structure of human SNX1 bar domain

Analyse Structure of human SNX1 bar domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4FZS
Type: protein
Length: 398 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorting nexin-1
UniProt: Q13596
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 2 distinct chains · 91% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sorting nexin-1	protein	209	92% helix, 0% strand	Q13596
B	Sorting nexin-1	protein	189	90% helix, 0% strand	Q13596

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	457	0.80	0.87	38	empty
2	62	0.32	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 2290 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4FZS · Structure of human SNX1 BAR domain · the same entry in another collection · chain A against A, TM-score 1.00
Q13596 · AlphaFold monomer V2.0 prediction for sorting nexin-1 (Q13596) · a predicted model of the same protein · chain A against A, TM-score 0.64

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13596
Elsewhere: RCSB PDB 4FZS · PDBe 4FZS · UniProt Q13596

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