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Activity and specificity of human aldolases

Analyse Activity and specificity of human aldolases in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1ALD
Type: protein
Length: 363 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aldolase a
EC: 4.1.2.13
UniProt: P04075
Pockets: 2 · best druggability 0.65

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Aldolase a (EC 4.1.2.13)	protein	363	45% helix, 14% strand	P04075

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	267	0.65	0.82	25	empty
2	253	0.61	0.80	39	empty

Compared structures

1ALD · Activity and specificity of human aldolases · the same entry in another collection · chain A against A, TM-score 1.00
P04075 · AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P04075) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04075
Elsewhere: RCSB PDB 1ALD · PDBe 1ALD · UniProt P04075

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