UniProt P04075
Fructose-bisphosphate aldolase A (P04075)
Fructose-bisphosphate aldolase A (UniProt P04075), EC 4.1.2.13: 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 45 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P04075
- Protein
- Fructose-bisphosphate aldolase A
- EC
- 4.1.2.13
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 45 · 6 records with a druggable one
Structures
17 records of P04075 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ALD | Activity and specificity of human aldolases | x-ray diffraction | A | — | 2 (best 0.65) |
| 1ALD | Activity and specificity of human aldolases | x-ray diffraction | A | — | — |
| 2ALD | Human muscle aldolase | x-ray diffraction | A | — | 2 (best 0.74) |
| 2ALD | Human muscle aldolase | x-ray diffraction | A | — | — |
| 4ALD | Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose 1,6-bisphosphate | x-ray diffraction | A | — | — |
| 4ALD | Human muscle fructose 1,6-bisphosphate aldolase complexed with fructose 1,6-bisphosphate | x-ray diffraction | A | — | — |
| 5KY6 | Human muscle fructose-1,6-bisphosphate aldolase | x-ray diffraction | A, B, C, D | — | 15 (best 0.88) |
| 5KY6 | Human muscle fructose-1,6-bisphosphate aldolase | x-ray diffraction | A, B, C, D | — | — |
| 6XMH | Human aldolase A wild type | x-ray diffraction | A, B | PO4 | — |
| 6XMH | Human aldolase a wild type | x-ray diffraction | A, B | PO4 | — |
| 6XML | Human aldolase A I98C | x-ray diffraction | A, B | PO4 | 7 (best 0.77) |
| 6XML | Human aldolase a I98C | x-ray diffraction | A, B | PO4 | — |
| 6XMM | Human aldolase A I98S | x-ray diffraction | A, B | PO4 | 7 (best 0.77) |
| 6XMM | Human aldolase a I98S | x-ray diffraction | A, B | PO4 | — |
| 6XMO | Human aldolase A I98F | x-ray diffraction | A, B | PO4 | 12 (best 0.63) |
| 6XMO | Human aldolase a I98F | x-ray diffraction | A, B | PO4 | — |
| P04075 | AlphaFold monomer V2.0 prediction for fructose-bisphosphate aldolase a (P04075) | predicted | A | — | — |
Ligands
- PO4 · Phosphate ion · in 8 records
Experiment against prediction
- 6XMH chain B against the predicted model P04075: TM-score 1.00, RMSD 0.39 Å
- 6XMH chain B against the predicted model P04075: TM-score 1.00, RMSD 0.39 Å
- 6XML chain A against the predicted model P04075: TM-score 1.00, RMSD 0.44 Å
- 6XML chain A against the predicted model P04075: TM-score 1.00, RMSD 0.44 Å
- 6XMH chain A against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
- 6XMH chain A against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
- 6XMM chain A against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
- 6XMM chain A against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
- 6XMM chain B against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
- 6XMM chain B against the predicted model P04075: TM-score 1.00, RMSD 0.45 Å
Elsewhere
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